Goserelin vs Gonadotropin-releasing hormone
A depot GnRH agonist; same flare-then-suppression mechanism as leuprolide. The pulsatile hypothalamic driver of the reproductive axis. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Goserelin | Gonadotropin-releasing hormone GnRH | |
|---|---|---|
| Also known as | Zoladex | — |
| Type | Analog | Endogenous |
| Evidence | Established | Established |
| Family | Reproductive & gonadal | Reproductive & gonadal |
| Class | GnRH receptor agonist (decapeptide analog) | Decapeptide (10 aa) |
| Receptor | GnRH receptor (GnRHR) | GnRH receptor (GnRHR), a class A GPCR |
| Molecular weight | ~1,269.4 Da | ~1,182.3 Da |
| Half-life | ||
| Based on | Gonadotropin-releasing hormone | Native hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Goserelin and Gonadotropin-releasing hormone?
- Goserelin is an engineered analog based on Gonadotropin-releasing hormone; Gonadotropin-releasing hormone is an endogenous hormone. Goserelin signals at GnRH receptor (GnRHR); Gonadotropin-releasing hormone signals at GnRH receptor (GnRHR), a class A GPCR.
- How do the half-lives of Goserelin and GnRH compare?
- The reported circulating half-life of Goserelin is ~4–5 h (implant depot); Gonadotropin-releasing hormone is ~2–4 min. These are reference values for the native or representative form — educational only, not dosing advice.
- Is Goserelin the same as Zoladex?
- Zoladex is a brand name of Goserelin. This comparison describes the molecules, not branded products.
Prefer the other order? Gonadotropin-releasing hormone vs Goserelin. Or open the interactive comparison tool to add more molecules.