Gonadotropin-releasing hormone vs Goserelin
The pulsatile hypothalamic driver of the reproductive axis. A depot GnRH agonist; same flare-then-suppression mechanism as leuprolide. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Gonadotropin-releasing hormone GnRH | Goserelin | |
|---|---|---|
| Also known as | — | Zoladex |
| Type | Endogenous | Analog |
| Evidence | Established | Established |
| Family | Reproductive & gonadal | Reproductive & gonadal |
| Class | Decapeptide (10 aa) | GnRH receptor agonist (decapeptide analog) |
| Receptor | GnRH receptor (GnRHR), a class A GPCR | GnRH receptor (GnRHR) |
| Molecular weight | ~1,182.3 Da | ~1,269.4 Da |
| Half-life | ||
| Based on | Native hormone | Gonadotropin-releasing hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Gonadotropin-releasing hormone and Goserelin?
- Gonadotropin-releasing hormone is an endogenous hormone; Goserelin is an engineered analog based on Gonadotropin-releasing hormone. Gonadotropin-releasing hormone signals at GnRH receptor (GnRHR), a class A GPCR; Goserelin signals at GnRH receptor (GnRHR).
- How do the half-lives of GnRH and Goserelin compare?
- The reported circulating half-life of Gonadotropin-releasing hormone is ~2–4 min; Goserelin is ~4–5 h (implant depot). These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Goserelin vs Gonadotropin-releasing hormone. Or open the interactive comparison tool to add more molecules.