Goserelin
A depot GnRH agonist; same flare-then-suppression mechanism as leuprolide.
Identity
- Class
- GnRH receptor agonist (decapeptide analog)
- Source
- Synthetic analog of GnRH
- Receptor
- GnRH receptor (GnRHR)
Key properties
Molecular weight
~1,269.4 Da
Approximate values for the native hormone. Engineered analogs are often deliberately larger and far longer-acting.
Mechanism
Goserelin is a GnRH agonist delivered as a slow-release implant. Like other agonists, continuous exposure desensitizes the GnRH receptor after an initial flare, producing sustained suppression of the gonadotropins and downstream sex steroids.
Reference notes
- Delivered as a subcutaneous depot implant for steady, long-term exposure.
- Shares the agonist flare-then-desensitization mechanism with leuprolide.
- Illustrates the pulsatility principle: continuous GnRH signaling suppresses the axis.
Selected literature
Curated peer-reviewed reviews, sourced from PubMed. Selected for relevance, not exhaustive — open any entry on PubMed for the full record and its primary citations.
- 1.Goserelin · , 2012 · PMID 31644049
- 2.Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials · The Lancet. Oncology, 2022 · PMID 35123662