Goserelin vs Cetrorelix
A depot GnRH agonist; same flare-then-suppression mechanism as leuprolide. A GnRH antagonist — immediate suppression with no flare. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Goserelin | Cetrorelix | |
|---|---|---|
| Also known as | Zoladex | Cetrotide |
| Type | Analog | Analog |
| Evidence | Established | Established |
| Family | Reproductive & gonadal | Reproductive & gonadal |
| Class | GnRH receptor agonist (decapeptide analog) | GnRH receptor antagonist (decapeptide) |
| Receptor | GnRH receptor (GnRHR) | GnRH receptor (GnRHR) — competitive antagonist |
| Molecular weight | ~1,269.4 Da | ~1,431 Da |
| Half-life | ||
| Based on | Gonadotropin-releasing hormone | Gonadotropin-releasing hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Goserelin and Cetrorelix?
- Goserelin is an engineered analog based on Gonadotropin-releasing hormone; Cetrorelix is an engineered analog based on Gonadotropin-releasing hormone. Goserelin signals at GnRH receptor (GnRHR); Cetrorelix signals at GnRH receptor (GnRHR) — competitive antagonist.
- How do the half-lives of Goserelin and Cetrorelix compare?
- The reported circulating half-life of Goserelin is ~4–5 h (implant depot); Cetrorelix is ~5 h (immediate-release). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Goserelin the same as Zoladex?
- Zoladex is a brand name of Goserelin. This comparison describes the molecules, not branded products.
Prefer the other order? Cetrorelix vs Goserelin. Or open the interactive comparison tool to add more molecules.