Cetrorelix vs Goserelin
A GnRH antagonist — immediate suppression with no flare. A depot GnRH agonist; same flare-then-suppression mechanism as leuprolide. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Cetrorelix | Goserelin | |
|---|---|---|
| Also known as | Cetrotide | Zoladex |
| Type | Analog | Analog |
| Evidence | Established | Established |
| Family | Reproductive & gonadal | Reproductive & gonadal |
| Class | GnRH receptor antagonist (decapeptide) | GnRH receptor agonist (decapeptide analog) |
| Receptor | GnRH receptor (GnRHR) — competitive antagonist | GnRH receptor (GnRHR) |
| Molecular weight | ~1,431 Da | ~1,269.4 Da |
| Half-life | ||
| Based on | Gonadotropin-releasing hormone | Gonadotropin-releasing hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Cetrorelix and Goserelin?
- Cetrorelix is an engineered analog based on Gonadotropin-releasing hormone; Goserelin is an engineered analog based on Gonadotropin-releasing hormone. Cetrorelix signals at GnRH receptor (GnRHR) — competitive antagonist; Goserelin signals at GnRH receptor (GnRHR).
- How do the half-lives of Cetrorelix and Goserelin compare?
- The reported circulating half-life of Cetrorelix is ~5 h (immediate-release); Goserelin is ~4–5 h (implant depot). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Cetrorelix the same as Cetrotide?
- Cetrotide is a brand name of Cetrorelix. This comparison describes the molecules, not branded products.
Prefer the other order? Goserelin vs Cetrorelix. Or open the interactive comparison tool to add more molecules.