Analog comparison
Put a native hormone next to the analogs engineered from it — or compare any molecules in the catalog. The same receptor, a different half-life: see how protease resistance and acylation stretch a peptide’s duration from minutes to days while the underlying mechanism stays the same.
| Type | Endogenous | Analog | Analog | Analog |
|---|---|---|---|---|
| Evidence | Established | Established | Investigational | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic | Incretins & metabolic | Incretins & metabolic |
| Class | Islet amyloid polypeptide (37 aa) | Amylin analog (synthetic 37 aa peptide) | Long-acting amylin analog (acylated peptide) | Unimolecular GLP-1 + amylin receptor agonist (peptide) |
| Receptor | Amylin receptors (calcitonin receptor + RAMP complexes) | Amylin receptors (calcitonin receptor + RAMP) | Amylin receptors (calcitonin receptor + RAMP) | GLP-1 receptor + amylin receptors |
| Molecular weight | ~3,903.3 Da | — | — | — |
| Half-life | — | — | — | |
| Based on | Native hormone | Amylin | Amylin | Amylin |
Half-life bars are on a logarithmic scale across the molecules shown, so a minutes-long native peptide and a once-weekly analog stay legible together. Reference values for the native or representative form — educational only, not medical or dosing advice.
How to read a lineage
Most engineered peptides are not new mechanisms — they are durability solutions. An analog usually binds the same receptor as its native hormone; what changes is how long it survives in circulation. Native GLP-1 is cleared by DPP-4 in a minute or two, while its acylated analogs bind albumin and persist for days.
Reading left to right along a lineage, watch three columns: receptor (often identical — the mechanism is conserved), molecular weight (analogs are deliberately larger, carrying fatty-acid chains), and half-life (the payoff — the engineering target).
Want the dosing consequences of those half-lives? Each molecule links straight into the half-life & dosing calculator.
Reference-grade approximations for the native or representative form of each molecule. Engineered formulations (depots, extended-release) differ substantially. Educational only — not medical advice, dosing guidance, or a recommendation to use any substance.