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PeptideHormone

Lanreotide

A depot somatostatin analog, similar in action to octreotide.

Also known as Somatuline.

AnalogEstablishedBased on SomatostatinCompare with SST Compare lineage

The braking signal again, this time formulated to release over weeks: in this field, delivery is as much of the invention as the sequence.

Identity

Class
Somatostatin analog (cyclic octapeptide)
Source
Synthetic analog of somatostatin
Receptor
Somatostatin receptors (SSTR2 and SSTR5 preferential)

Key properties

Evidence floorClinicalREF1CLIN1
Molecular weight
~1,096.3 Da
REF
Half-life (native)
depot-dominant (autogel acts over weeks)
CLIN

Approximate values for the native hormone; engineered analogs are often deliberately larger and far longer-acting. Each figure carries its own provenance tier, and the floor is the weakest of them - the Standard.

Mechanism

Lanreotide is a somatostatin analog formulated as a long-acting depot (autogel) that releases over weeks, suppressing growth hormone and neuroendocrine secretion much like octreotide. Its prolonged depot kinetics are the practical contrast with the native peptide's minutes-long half-life.

Reference notes

  • Delivered as an extended-release depot acting over weeks.
  • Shares octreotide's SSTR2/5-preferential profile.
  • Used in acromegaly and neuroendocrine tumors.

Common questions

What is Lanreotide?
A depot somatostatin analog, similar in action to octreotide. Structurally it is Somatostatin analog (cyclic octapeptide).
How does Lanreotide work?
Lanreotide is a somatostatin analog formulated as a long-acting depot (autogel) that releases over weeks, suppressing growth hormone and neuroendocrine secretion much like octreotide. Its prolonged depot kinetics are the practical contrast with the native peptide's minutes-long half-life.
How strong is the evidence for Lanreotide?
PeptideHormone grades Lanreotide at the "Established" evidence tier — its mechanism and core effects are settled across the peer-reviewed literature. It is catalogued as an engineered analog built on an endogenous hormone, and the tier is an editorial judgment about the public literature that can change as the science does.
What is the half-life of Lanreotide?
The reported circulating half-life of Lanreotide is depot-dominant (autogel acts over weeks).
Is Lanreotide the same as Somatuline?
Somatuline is a brand name of Lanreotide — the same molecule in different approved presentations. This page is the molecule reference, not a prescribing guide.

Selected literature

Curated peer-reviewed reviews, sourced from PubMed. Selected for relevance, not exhaustive — open any entry on PubMed for the full record and its primary citations.

  1. 1.Acromegaly · Nature reviews. Disease primers, 2019 · PMID 30899019
  2. 2.Somatostatin Analogs in Clinical Practice: a Review · International journal of molecular sciences, 2020 · PMID 32121432

External references

Lanreotide in the public knowledge graph — the same entity resolved across the authoritative chemistry and protein databases.