A synthetic tetrapeptide promoted for longevity; limited independent evidence. Structurally it is Synthetic tetrapeptide (Ala-Glu-Asp-Gly).

How strong is the evidence for Epitalon?

PeptideHormone grades Epitalon at the "Limited" evidence tier — the evidence is sparse, older, or mostly community-reported. It is catalogued as a community research peptide outside the approved-drug system, and the tier is an editorial judgment about the public literature that can change as the science does.

What is the half-life of Epitalon?

The reported circulating half-life of Epitalon is Minutes (rapidly cleared).

Epitalon

A synthetic tetrapeptide promoted for longevity; limited independent evidence.

Research peptideLimited

Four residues carrying a very large claim. The longevity literature here is thin, largely from one group, and has not been independently reproduced.

Identity

Class: Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
Source: Synthetic; modeled on a pineal peptide preparation
Receptor: No established receptor; proposed effects on telomerase and pineal signaling

Key properties

Evidence floorPreclinicalREF1PRE1

Molecular weight

~390.4 Da

REF

Half-life (native)

Minutes (rapidly cleared)

PRE

Approximate values for the native hormone; engineered analogs are often deliberately larger and far longer-acting. Each figure carries its own provenance tier, and the floor is the weakest of them - the Standard.

Mechanism

Epitalon is a synthetic tetrapeptide promoted for anti-ageing effects, with proposed influence on telomerase activity and pineal/melatonin signaling. Much of the supporting work comes from a small number of research groups, and rigorous, independent human evidence is limited.

Reference notes

Its claims (telomerase, longevity) rest on limited and largely single-source evidence.
No well-established receptor or mechanism in humans.
A clear case for reading the evidence badge rather than the marketing.

Common questions

What is Epitalon?: A synthetic tetrapeptide promoted for longevity; limited independent evidence. Structurally it is Synthetic tetrapeptide (Ala-Glu-Asp-Gly).
How does Epitalon work?: Epitalon is a synthetic tetrapeptide promoted for anti-ageing effects, with proposed influence on telomerase activity and pineal/melatonin signaling. Much of the supporting work comes from a small number of research groups, and rigorous, independent human evidence is limited.
How strong is the evidence for Epitalon?: PeptideHormone grades Epitalon at the "Limited" evidence tier — the evidence is sparse, older, or mostly community-reported. It is catalogued as a community research peptide outside the approved-drug system, and the tier is an editorial judgment about the public literature that can change as the science does.
What is the half-life of Epitalon?: The reported circulating half-life of Epitalon is Minutes (rapidly cleared).

Selected literature

Curated peer-reviewed reviews, sourced from PubMed. Selected for relevance, not exhaustive — open any entry on PubMed for the full record and its primary citations.

1.Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties · International journal of molecular sciences, 2025 · PMID 40141333
2.Peptides and Ageing · Neuro endocrinology letters, 2002 · PMID 12374906

External references

Epitalon in the public knowledge graph — the same entity resolved across the authoritative chemistry and protein databases.