PeptideHormone

Epitalon

A synthetic tetrapeptide promoted for longevity; limited independent evidence.

Research peptideLimited

Identity

Class
Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
Source
Synthetic; modeled on a pineal peptide preparation
Receptor
No established receptor; proposed effects on telomerase and pineal signaling

Key properties

Molecular weight
~390.4 Da

Approximate values for the native hormone. Engineered analogs are often deliberately larger and far longer-acting.

Mechanism

Epitalon is a synthetic tetrapeptide promoted for anti-ageing effects, with proposed influence on telomerase activity and pineal/melatonin signaling. Much of the supporting work comes from a small number of research groups, and rigorous, independent human evidence is limited.

Reference notes

  • Its claims (telomerase, longevity) rest on limited and largely single-source evidence.
  • No well-established receptor or mechanism in humans.
  • A clear case for reading the evidence badge rather than the marketing.

Selected literature

Curated peer-reviewed reviews, sourced from PubMed. Selected for relevance, not exhaustive — open any entry on PubMed for the full record and its primary citations.

  1. 1.Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties · International journal of molecular sciences, 2025 · PMID 40141333
  2. 2.Peptides and Ageing · Neuro endocrinology letters, 2002 · PMID 12374906