Tirzepatide vs Glucose-dependent insulinotropic polypeptide
A dual GIP and GLP-1 receptor agonist — the first of the co-agonists. The second incretin, with distinct adipose and CNS biology. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Tirzepatide | Glucose-dependent insulinotropic polypeptide GIP | |
|---|---|---|
| Also known as | Mounjaro, Zepbound | — |
| Type | Analog | Endogenous |
| Evidence | Established | Established |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Dual GIP/GLP-1 receptor agonist (39 aa, acylated) | Incretin peptide (42 aa) |
| Receptor | GIP receptor + GLP-1 receptor | GIP receptor (GIPR), a class B GPCR |
| Molecular weight | ~4,813.5 Da | ~4,983.6 Da |
| Half-life | ||
| Based on | Glucose-dependent insulinotropic polypeptide | Native hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Tirzepatide and Glucose-dependent insulinotropic polypeptide?
- Tirzepatide is an engineered analog based on Glucose-dependent insulinotropic polypeptide; Glucose-dependent insulinotropic polypeptide is an endogenous hormone. Tirzepatide signals at GIP receptor + GLP-1 receptor; Glucose-dependent insulinotropic polypeptide signals at GIP receptor (GIPR), a class B GPCR.
- How do the half-lives of Tirzepatide and GIP compare?
- The reported circulating half-life of Tirzepatide is ~5 days (~120 h); Glucose-dependent insulinotropic polypeptide is ~5–7 min (native; DPP-4). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Tirzepatide the same as Mounjaro?
- Mounjaro, Zepbound are brand names of Tirzepatide. This comparison describes the molecules, not branded products.
Prefer the other order? Glucose-dependent insulinotropic polypeptide vs Tirzepatide. Or open the interactive comparison tool to add more molecules.