Bremelanotide vs Alpha-melanocyte-stimulating hormone
An FDA-approved melanocortin agonist for hypoactive sexual desire. The core melanocortin ligand — pigment, appetite, inflammation. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Bremelanotide PT-141 | Alpha-melanocyte-stimulating hormone α-MSH | |
|---|---|---|
| Also known as | Vyleesi | — |
| Type | Analog | Endogenous |
| Evidence | Clinical | Established |
| Family | Melanocortins | Melanocortins |
| Class | Cyclic heptapeptide melanocortin agonist (α-MSH analog) | POMC-derived peptide (13 aa) |
| Receptor | Melanocortin receptors (MC4R, with MC1R activity) | Melanocortin receptors MC1R, MC3R, MC4R, MC5R |
| Molecular weight | ~1,025.2 Da | ~1,664.9 Da |
| Half-life | ||
| Based on | Alpha-melanocyte-stimulating hormone | Native hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Bremelanotide and Alpha-melanocyte-stimulating hormone?
- Bremelanotide is an engineered analog based on Alpha-melanocyte-stimulating hormone; Alpha-melanocyte-stimulating hormone is an endogenous hormone. Bremelanotide signals at Melanocortin receptors (MC4R, with MC1R activity); Alpha-melanocyte-stimulating hormone signals at Melanocortin receptors MC1R, MC3R, MC4R, MC5R.
- How do the half-lives of PT-141 and α-MSH compare?
- The reported circulating half-life of Bremelanotide is ~2.5-3 h; Alpha-melanocyte-stimulating hormone is ~minutes (very short). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Bremelanotide the same as Vyleesi?
- Vyleesi is a brand name of Bremelanotide. This comparison describes the molecules, not branded products.
Prefer the other order? Alpha-melanocyte-stimulating hormone vs Bremelanotide. Or open the interactive comparison tool to add more molecules.