Pramlintide vs Cagrilintide
The first amylin analog — native amylin with its self-aggregation edited out. A long-acting amylin analog built for once-weekly dosing and GLP-1 pairing. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Pramlintide | Cagrilintide | |
|---|---|---|
| Also known as | Symlin | — |
| Type | Analog | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Amylin analog (synthetic 37 aa peptide) | Long-acting amylin analog (acylated peptide) |
| Receptor | Amylin receptors (calcitonin receptor + RAMP) | Amylin receptors (calcitonin receptor + RAMP) |
| Molecular weight | ~3,949.4 Da | ~4,408.9 Da |
| Half-life | ||
| Based on | Amylin | Amylin |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Pramlintide and Cagrilintide?
- Pramlintide is an engineered analog based on Amylin; Cagrilintide is an engineered analog based on Amylin. Pramlintide signals at Amylin receptors (calcitonin receptor + RAMP); Cagrilintide signals at Amylin receptors (calcitonin receptor + RAMP).
- How do the half-lives of Pramlintide and Cagrilintide compare?
- The reported circulating half-life of Pramlintide is ~48 min; Cagrilintide is ~7 days (159-195 h). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Pramlintide the same as Symlin?
- Symlin is a brand name of Pramlintide. This comparison describes the molecules, not branded products.
Prefer the other order? Cagrilintide vs Pramlintide. Or open the interactive comparison tool to add more molecules.