Cagrilintide vs Pramlintide
A long-acting amylin analog built for once-weekly dosing and GLP-1 pairing. The first amylin analog — native amylin with its self-aggregation edited out. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Cagrilintide | Pramlintide | |
|---|---|---|
| Also known as | — | Symlin |
| Type | Analog | Analog |
| Evidence | Investigational | Established |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Long-acting amylin analog (acylated peptide) | Amylin analog (synthetic 37 aa peptide) |
| Receptor | Amylin receptors (calcitonin receptor + RAMP) | Amylin receptors (calcitonin receptor + RAMP) |
| Molecular weight | ~4,408.9 Da | ~3,949.4 Da |
| Half-life | ||
| Based on | Amylin | Amylin |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Cagrilintide and Pramlintide?
- Cagrilintide is an engineered analog based on Amylin; Pramlintide is an engineered analog based on Amylin. Cagrilintide signals at Amylin receptors (calcitonin receptor + RAMP); Pramlintide signals at Amylin receptors (calcitonin receptor + RAMP).
- How do the half-lives of Cagrilintide and Pramlintide compare?
- The reported circulating half-life of Cagrilintide is ~7 days (159-195 h); Pramlintide is ~48 min. These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Pramlintide vs Cagrilintide. Or open the interactive comparison tool to add more molecules.