Pramlintide vs Amylin
The first amylin analog — native amylin with its self-aggregation edited out. Co-secreted with insulin; the satiety and gastric-emptying partner. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Pramlintide | Amylin IAPP | |
|---|---|---|
| Also known as | Symlin | — |
| Type | Analog | Endogenous |
| Evidence | Established | Established |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Amylin analog (synthetic 37 aa peptide) | Islet amyloid polypeptide (37 aa) |
| Receptor | Amylin receptors (calcitonin receptor + RAMP) | Amylin receptors (calcitonin receptor + RAMP complexes) |
| Molecular weight | ~3,949.4 Da | ~3,903.3 Da |
| Half-life | ||
| Based on | Amylin | Native hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Pramlintide and Amylin?
- Pramlintide is an engineered analog based on Amylin; Amylin is an endogenous hormone. Pramlintide signals at Amylin receptors (calcitonin receptor + RAMP); Amylin signals at Amylin receptors (calcitonin receptor + RAMP complexes).
- How do the half-lives of Pramlintide and IAPP compare?
- The reported circulating half-life of Pramlintide is ~48 min; Amylin is ~13 min (native). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Pramlintide the same as Symlin?
- Symlin is a brand name of Pramlintide. This comparison describes the molecules, not branded products.
Prefer the other order? Amylin vs Pramlintide. Or open the interactive comparison tool to add more molecules.