Amylin vs Pramlintide
Co-secreted with insulin; the satiety and gastric-emptying partner. The first amylin analog — native amylin with its self-aggregation edited out. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Amylin IAPP | Pramlintide | |
|---|---|---|
| Also known as | — | Symlin |
| Type | Endogenous | Analog |
| Evidence | Established | Established |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Islet amyloid polypeptide (37 aa) | Amylin analog (synthetic 37 aa peptide) |
| Receptor | Amylin receptors (calcitonin receptor + RAMP complexes) | Amylin receptors (calcitonin receptor + RAMP) |
| Molecular weight | ~3,903.3 Da | ~3,949.4 Da |
| Half-life | ||
| Based on | Native hormone | Amylin |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Amylin and Pramlintide?
- Amylin is an endogenous hormone; Pramlintide is an engineered analog based on Amylin. Amylin signals at Amylin receptors (calcitonin receptor + RAMP complexes); Pramlintide signals at Amylin receptors (calcitonin receptor + RAMP).
- How do the half-lives of IAPP and Pramlintide compare?
- The reported circulating half-life of Amylin is ~13 min (native); Pramlintide is ~48 min. These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Pramlintide vs Amylin. Or open the interactive comparison tool to add more molecules.