Mechano growth factor vs Insulin-like growth factor 1
IGF-1's local, load-triggered splice variant — a repair pulse, not a systemic signal. The hepatic mediator of growth hormone's anabolic effects. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Mechano growth factor MGF | Insulin-like growth factor 1 IGF-1 | |
|---|---|---|
| Also known as | — | — |
| Type | Research | Endogenous |
| Evidence | Preclinical | Established |
| Family | Growth & repair | Growth & repair |
| Class | IGF-1 splice variant (IGF-1Ec); the research peptide is its C-terminal E-domain (~24 aa) | Single-chain growth factor (70 aa) |
| Receptor | The IGF-1 core acts at IGF-1R; the distinct E-domain peptide's receptor is unidentified | IGF-1 receptor (IGF-1R, a receptor tyrosine kinase) |
| Molecular weight | — | ~7,649 Da |
| Half-life | Minutes (E-domain peptide); longer as PEG-MGF | |
| Based on | Insulin-like growth factor 1 | Native hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Mechano growth factor and Insulin-like growth factor 1?
- Mechano growth factor is a research peptide based on Insulin-like growth factor 1; Insulin-like growth factor 1 is an endogenous hormone. Mechano growth factor signals at The IGF-1 core acts at IGF-1R; the distinct E-domain peptide's receptor is unidentified; Insulin-like growth factor 1 signals at IGF-1 receptor (IGF-1R, a receptor tyrosine kinase).
- How do the half-lives of MGF and IGF-1 compare?
- The reported circulating half-life of Mechano growth factor is Minutes (E-domain peptide); longer as PEG-MGF; Insulin-like growth factor 1 is ~12–16 h bound to IGFBPs (~10 min free). These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Insulin-like growth factor 1 vs Mechano growth factor. Or open the interactive comparison tool to add more molecules.