Insulin-like growth factor 1 vs Mechano growth factor
The hepatic mediator of growth hormone's anabolic effects. IGF-1's local, load-triggered splice variant — a repair pulse, not a systemic signal. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Insulin-like growth factor 1 IGF-1 | Mechano growth factor MGF | |
|---|---|---|
| Also known as | — | — |
| Type | Endogenous | Research |
| Evidence | Established | Preclinical |
| Family | Growth & repair | Growth & repair |
| Class | Single-chain growth factor (70 aa) | IGF-1 splice variant (IGF-1Ec); the research peptide is its C-terminal E-domain (~24 aa) |
| Receptor | IGF-1 receptor (IGF-1R, a receptor tyrosine kinase) | The IGF-1 core acts at IGF-1R; the distinct E-domain peptide's receptor is unidentified |
| Molecular weight | ~7,649 Da | — |
| Half-life | Minutes (E-domain peptide); longer as PEG-MGF | |
| Based on | Native hormone | Insulin-like growth factor 1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Insulin-like growth factor 1 and Mechano growth factor?
- Insulin-like growth factor 1 is an endogenous hormone; Mechano growth factor is a research peptide based on Insulin-like growth factor 1. Insulin-like growth factor 1 signals at IGF-1 receptor (IGF-1R, a receptor tyrosine kinase); Mechano growth factor signals at The IGF-1 core acts at IGF-1R; the distinct E-domain peptide's receptor is unidentified.
- How do the half-lives of IGF-1 and MGF compare?
- The reported circulating half-life of Insulin-like growth factor 1 is ~12–16 h bound to IGFBPs (~10 min free); Mechano growth factor is Minutes (E-domain peptide); longer as PEG-MGF. These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Mechano growth factor vs Insulin-like growth factor 1. Or open the interactive comparison tool to add more molecules.