Liraglutide vs Exenatide
A once-daily GLP-1 receptor agonist; an earlier acylated analog. A GLP-1 receptor agonist derived from Gila monster venom (exendin-4). Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Liraglutide | Exenatide | |
|---|---|---|
| Also known as | Victoza, Saxenda | Byetta, Bydureon |
| Type | Analog | Analog |
| Evidence | Established | Established |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GLP-1 receptor agonist (acylated, 31 aa) | GLP-1 receptor agonist (exendin-4, 39 aa) |
| Receptor | GLP-1 receptor (GLP-1R) | GLP-1 receptor (GLP-1R) |
| Molecular weight | ~3,751.2 Da | ~4,186.6 Da |
| Half-life | ||
| Based on | Glucagon-like peptide-1 | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Liraglutide and Exenatide?
- Liraglutide is an engineered analog based on Glucagon-like peptide-1; Exenatide is an engineered analog based on Glucagon-like peptide-1. Liraglutide signals at GLP-1 receptor (GLP-1R); Exenatide signals at GLP-1 receptor (GLP-1R).
- How do the half-lives of Liraglutide and Exenatide compare?
- The reported circulating half-life of Liraglutide is ~13 h; Exenatide is ~2.4 h (immediate-release). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Liraglutide the same as Victoza?
- Victoza, Saxenda are brand names of Liraglutide. This comparison describes the molecules, not branded products.
Prefer the other order? Exenatide vs Liraglutide. Or open the interactive comparison tool to add more molecules.