Exenatide vs Liraglutide
A GLP-1 receptor agonist derived from Gila monster venom (exendin-4). A once-daily GLP-1 receptor agonist; an earlier acylated analog. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Exenatide | Liraglutide | |
|---|---|---|
| Also known as | Byetta, Bydureon | Victoza, Saxenda |
| Type | Analog | Analog |
| Evidence | Established | Established |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GLP-1 receptor agonist (exendin-4, 39 aa) | GLP-1 receptor agonist (acylated, 31 aa) |
| Receptor | GLP-1 receptor (GLP-1R) | GLP-1 receptor (GLP-1R) |
| Molecular weight | ~4,186.6 Da | ~3,751.2 Da |
| Half-life | ||
| Based on | Glucagon-like peptide-1 | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Exenatide and Liraglutide?
- Exenatide is an engineered analog based on Glucagon-like peptide-1; Liraglutide is an engineered analog based on Glucagon-like peptide-1. Exenatide signals at GLP-1 receptor (GLP-1R); Liraglutide signals at GLP-1 receptor (GLP-1R).
- How do the half-lives of Exenatide and Liraglutide compare?
- The reported circulating half-life of Exenatide is ~2.4 h (immediate-release); Liraglutide is ~13 h. These are reference values for the native or representative form — educational only, not dosing advice.
- Is Exenatide the same as Byetta?
- Byetta, Bydureon are brand names of Exenatide. This comparison describes the molecules, not branded products.
Prefer the other order? Liraglutide vs Exenatide. Or open the interactive comparison tool to add more molecules.