Leuprolide vs Cetrorelix
A GnRH agonist that suppresses the axis through continuous stimulation. A GnRH antagonist — immediate suppression with no flare. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Leuprolide | Cetrorelix | |
|---|---|---|
| Also known as | Lupron, Eligard | Cetrotide |
| Type | Analog | Analog |
| Evidence | Established | Established |
| Family | Reproductive & gonadal | Reproductive & gonadal |
| Class | GnRH receptor agonist (nonapeptide analog) | GnRH receptor antagonist (decapeptide) |
| Receptor | GnRH receptor (GnRHR) | GnRH receptor (GnRHR) — competitive antagonist |
| Molecular weight | ~1,209.4 Da | ~1,431 Da |
| Half-life | ||
| Based on | Gonadotropin-releasing hormone | Gonadotropin-releasing hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Leuprolide and Cetrorelix?
- Leuprolide is an engineered analog based on Gonadotropin-releasing hormone; Cetrorelix is an engineered analog based on Gonadotropin-releasing hormone. Leuprolide signals at GnRH receptor (GnRHR); Cetrorelix signals at GnRH receptor (GnRHR) — competitive antagonist.
- How do the half-lives of Leuprolide and Cetrorelix compare?
- The reported circulating half-life of Leuprolide is ~3 h (depot formulations act for months); Cetrorelix is ~5 h (immediate-release). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Leuprolide the same as Lupron?
- Lupron, Eligard are brand names of Leuprolide. This comparison describes the molecules, not branded products.
Prefer the other order? Cetrorelix vs Leuprolide. Or open the interactive comparison tool to add more molecules.