Cetrorelix vs Leuprolide
A GnRH antagonist — immediate suppression with no flare. A GnRH agonist that suppresses the axis through continuous stimulation. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Cetrorelix | Leuprolide | |
|---|---|---|
| Also known as | Cetrotide | Lupron, Eligard |
| Type | Analog | Analog |
| Evidence | Established | Established |
| Family | Reproductive & gonadal | Reproductive & gonadal |
| Class | GnRH receptor antagonist (decapeptide) | GnRH receptor agonist (nonapeptide analog) |
| Receptor | GnRH receptor (GnRHR) — competitive antagonist | GnRH receptor (GnRHR) |
| Molecular weight | ~1,431 Da | ~1,209.4 Da |
| Half-life | ||
| Based on | Gonadotropin-releasing hormone | Gonadotropin-releasing hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Cetrorelix and Leuprolide?
- Cetrorelix is an engineered analog based on Gonadotropin-releasing hormone; Leuprolide is an engineered analog based on Gonadotropin-releasing hormone. Cetrorelix signals at GnRH receptor (GnRHR) — competitive antagonist; Leuprolide signals at GnRH receptor (GnRHR).
- How do the half-lives of Cetrorelix and Leuprolide compare?
- The reported circulating half-life of Cetrorelix is ~5 h (immediate-release); Leuprolide is ~3 h (depot formulations act for months). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Cetrorelix the same as Cetrotide?
- Cetrotide is a brand name of Cetrorelix. This comparison describes the molecules, not branded products.
Prefer the other order? Leuprolide vs Cetrorelix. Or open the interactive comparison tool to add more molecules.