Goserelin vs Leuprolide
A depot GnRH agonist; same flare-then-suppression mechanism as leuprolide. A GnRH agonist that suppresses the axis through continuous stimulation. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Goserelin | Leuprolide | |
|---|---|---|
| Also known as | Zoladex | Lupron, Eligard |
| Type | Analog | Analog |
| Evidence | Established | Established |
| Family | Reproductive & gonadal | Reproductive & gonadal |
| Class | GnRH receptor agonist (decapeptide analog) | GnRH receptor agonist (nonapeptide analog) |
| Receptor | GnRH receptor (GnRHR) | GnRH receptor (GnRHR) |
| Molecular weight | ~1,269.4 Da | ~1,209.4 Da |
| Half-life | ||
| Based on | Gonadotropin-releasing hormone | Gonadotropin-releasing hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Goserelin and Leuprolide?
- Goserelin is an engineered analog based on Gonadotropin-releasing hormone; Leuprolide is an engineered analog based on Gonadotropin-releasing hormone. Goserelin signals at GnRH receptor (GnRHR); Leuprolide signals at GnRH receptor (GnRHR).
- How do the half-lives of Goserelin and Leuprolide compare?
- The reported circulating half-life of Goserelin is ~4–5 h (implant depot); Leuprolide is ~3 h (depot formulations act for months). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Goserelin the same as Zoladex?
- Zoladex is a brand name of Goserelin. This comparison describes the molecules, not branded products.
Prefer the other order? Leuprolide vs Goserelin. Or open the interactive comparison tool to add more molecules.