PeptideHormone

Peptide YYPYY

A post-meal satiety signal from intestinal L-cells.

EndogenousEstablished

Identity

Class
PP-fold peptide (36 aa); active PYY3-36 form
Source
Intestinal L-cells (with GLP-1)
Receptor
Y2 receptor (for the circulating PYY3-36 form)

Key properties

Molecular weight
≈ 4,309.7 Da
Half-life (native)
~minutes
Model dosing

Approximate values for the native hormone. Engineered analogs are often deliberately larger and far longer-acting.

Mechanism

Released after meals from the same L-cells that produce GLP-1, PYY (as PYY3-36) acts at Y2 receptors to reduce appetite. It is one of several converging gut signals that report fullness to the brain.

Reference notes

  • PYY and GLP-1 are co-secreted, directly linking this family to the incretin axis.
  • The truncated PYY3-36 form is the physiologically relevant circulating species.
  • Satiety is multi-signal — PYY is one contributor, not the single 'fullness hormone'.

Selected literature

Curated peer-reviewed reviews, sourced from PubMed. Selected for relevance, not exhaustive — open any entry on PubMed for the full record and its primary citations.

  1. 1.Incretin hormones: Their role in health and disease · Diabetes, obesity & metabolism, 2018 · PMID 29364588
  2. 2.Gut hormones and appetite regulation · Current opinion in endocrinology, diabetes, and obesity, 2024 · PMID 38511400