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PeptideHormone

Tirzepatide vs Survodutide

A dual GIP and GLP-1 receptor agonist — the first of the co-agonists. A dual glucagon and GLP-1 receptor agonist — the co-agonist that skips GIP and aims at the liver. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.

Tirzepatide
Survodutide
BI 456906
Also known asMounjaro, Zepbound—
TypeAnalogAnalog
EvidenceEstablishedInvestigational
FamilyIncretins & metabolicIncretins & metabolic
ClassDual GIP/GLP-1 receptor agonist (39 aa, acylated)Glucagon/GLP-1 dual receptor agonist (acylated peptide)
Receptor / targetGIP receptor + GLP-1 receptorGlucagon receptor (GCGR) + GLP-1 receptor
Molecular weight~4,813.5 Da≈4,800 Da
Half-life
~5 days (~120 h)
Model dosing
engineered for once-weekly dosing
Based onGlucose-dependent insulinotropic polypeptideGlucagon-like peptide-1

Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.

Common questions

What is the difference between Tirzepatide and Survodutide?
Tirzepatide is an engineered analog based on Glucose-dependent insulinotropic polypeptide; Survodutide is an engineered analog based on Glucagon-like peptide-1. Tirzepatide signals at GIP receptor + GLP-1 receptor; Survodutide signals at Glucagon receptor (GCGR) + GLP-1 receptor.
How do the half-lives of Tirzepatide and BI 456906 compare?
The reported circulating half-life of Tirzepatide is ~5 days (~120 h); Survodutide is engineered for once-weekly dosing. These are reference values for the native or representative form — educational only, not dosing advice.
Is Tirzepatide the same as Mounjaro?
Mounjaro, Zepbound are brand names of Tirzepatide. This comparison describes the molecules, not branded products.

Prefer the other order? Survodutide vs Tirzepatide. Or open the interactive comparison tool to add more molecules.