Tirzepatide vs Eloralintide
A dual GIP and GLP-1 receptor agonist — the first of the co-agonists. A selective, long-acting amylin agonist that reaches GLP-1-class weight loss without touching the GLP-1 receptor. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Tirzepatide | Eloralintide | |
|---|---|---|
| Also known as | Mounjaro, Zepbound | — |
| Type | Analog | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Dual GIP/GLP-1 receptor agonist (39 aa, acylated) | Selective long-acting amylin analog (acylated 37 aa peptide) |
| Receptor / target | GIP receptor + GLP-1 receptor | Amylin receptors (calcitonin receptor + RAMP), AMY1-selective |
| Molecular weight | ~4,813.5 Da | ~4,526 Da |
| Half-life | ||
| Based on | Glucose-dependent insulinotropic polypeptide | Amylin |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Tirzepatide and Eloralintide?
- Tirzepatide is an engineered analog based on Glucose-dependent insulinotropic polypeptide; Eloralintide is an engineered analog based on Amylin. Tirzepatide signals at GIP receptor + GLP-1 receptor; Eloralintide signals at Amylin receptors (calcitonin receptor + RAMP), AMY1-selective.
- How do the half-lives of Tirzepatide and Eloralintide compare?
- The reported circulating half-life of Tirzepatide is ~5 days (~120 h); Eloralintide is ~13–15 days (310–366 h). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Tirzepatide the same as Mounjaro?
- Mounjaro, Zepbound are brand names of Tirzepatide. This comparison describes the molecules, not branded products.
Prefer the other order? Eloralintide vs Tirzepatide. Or open the interactive comparison tool to add more molecules.