Semaglutide vs Maridebart cafraglutide
A long-acting GLP-1 receptor agonist engineered for once-weekly dosing. GLP-1 agonism paired with GIP receptor antagonism — the opposite GIP direction to tirzepatide. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Semaglutide | Maridebart cafraglutide MariTide | |
|---|---|---|
| Also known as | Ozempic, Wegovy, Rybelsus | — |
| Type | Analog | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GLP-1 receptor agonist (acylated peptide, 31 aa) | GLP-1 agonist–GIP-antagonist peptide–antibody conjugate |
| Receptor | GLP-1 receptor (GLP-1R) | GLP-1 receptor (agonist) + GIP receptor (antagonist) |
| Molecular weight | ~4,113.6 Da | ≈150,000 Da |
| Half-life | ||
| Based on | Glucagon-like peptide-1 | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Semaglutide and Maridebart cafraglutide?
- Semaglutide is an engineered analog based on Glucagon-like peptide-1; Maridebart cafraglutide is an engineered analog based on Glucagon-like peptide-1. Semaglutide signals at GLP-1 receptor (GLP-1R); Maridebart cafraglutide signals at GLP-1 receptor (agonist) + GIP receptor (antagonist).
- How do the half-lives of Semaglutide and MariTide compare?
- The reported circulating half-life of Semaglutide is ~7 days (~165 h); Maridebart cafraglutide is ~21 days (monthly dosing). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Semaglutide the same as Ozempic?
- Ozempic, Wegovy, Rybelsus are brand names of Semaglutide. This comparison describes the molecules, not branded products.
Prefer the other order? Maridebart cafraglutide vs Semaglutide. Or open the interactive comparison tool to add more molecules.