Semaglutide vs Cagrilintide
A long-acting GLP-1 receptor agonist engineered for once-weekly dosing. A long-acting amylin analog built for once-weekly dosing and GLP-1 pairing. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Semaglutide | Cagrilintide | |
|---|---|---|
| Also known as | Ozempic, Wegovy, Rybelsus | — |
| Type | Analog | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GLP-1 receptor agonist (acylated peptide, 31 aa) | Long-acting amylin analog (acylated peptide) |
| Receptor | GLP-1 receptor (GLP-1R) | Amylin receptors (calcitonin receptor + RAMP) |
| Molecular weight | ~4,113.6 Da | ~4,408.9 Da |
| Half-life | ||
| Based on | Glucagon-like peptide-1 | Amylin |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Semaglutide and Cagrilintide?
- Semaglutide is an engineered analog based on Glucagon-like peptide-1; Cagrilintide is an engineered analog based on Amylin. Semaglutide signals at GLP-1 receptor (GLP-1R); Cagrilintide signals at Amylin receptors (calcitonin receptor + RAMP).
- How do the half-lives of Semaglutide and Cagrilintide compare?
- The reported circulating half-life of Semaglutide is ~7 days (~165 h); Cagrilintide is ~7 days (159-195 h). These are reference values for the native or representative form — educational only, not dosing advice.
- Is Semaglutide the same as Ozempic?
- Ozempic, Wegovy, Rybelsus are brand names of Semaglutide. This comparison describes the molecules, not branded products.
Prefer the other order? Cagrilintide vs Semaglutide. Or open the interactive comparison tool to add more molecules.