Retatrutide vs Semaglutide
An investigational GIP/GLP-1/glucagon triple receptor agonist. A long-acting GLP-1 receptor agonist engineered for once-weekly dosing. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Retatrutide | Semaglutide | |
|---|---|---|
| Also known as | — | Ozempic, Wegovy, Rybelsus |
| Type | Analog | Analog |
| Evidence | Investigational | Established |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GIP/GLP-1/glucagon triple agonist (acylated peptide) | GLP-1 receptor agonist (acylated peptide, 31 aa) |
| Receptor | GIP + GLP-1 + glucagon receptors | GLP-1 receptor (GLP-1R) |
| Molecular weight | ≈4,900 Da | ~4,113.6 Da |
| Half-life | ||
| Based on | Glucagon-like peptide-1 | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Retatrutide and Semaglutide?
- Retatrutide is an engineered analog based on Glucagon-like peptide-1; Semaglutide is an engineered analog based on Glucagon-like peptide-1. Retatrutide signals at GIP + GLP-1 + glucagon receptors; Semaglutide signals at GLP-1 receptor (GLP-1R).
- How do the half-lives of Retatrutide and Semaglutide compare?
- The reported circulating half-life of Retatrutide is ~6 days; Semaglutide is ~7 days (~165 h). These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Semaglutide vs Retatrutide. Or open the interactive comparison tool to add more molecules.