Mechano growth factor vs Long R3 IGF-1
IGF-1's local, load-triggered splice variant — a repair pulse, not a systemic signal. IGF-1 re-engineered to slip past its binding proteins — more free signal, for longer. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Mechano growth factor MGF | Long R3 IGF-1 IGF-1 LR3 | |
|---|---|---|
| Also known as | — | — |
| Type | Research | Analog |
| Evidence | Preclinical | Preclinical |
| Family | Growth & repair | Growth & repair |
| Class | IGF-1 splice variant (IGF-1Ec); the research peptide is its C-terminal E-domain (~24 aa) | 83-aa IGF-1 analog (Arg³ substitution + 13-aa N-terminal extension) |
| Receptor | The IGF-1 core acts at IGF-1R; the distinct E-domain peptide's receptor is unidentified | IGF-1 receptor (IGF-1R), a receptor tyrosine kinase |
| Molecular weight | — | ≈9,111 Da |
| Half-life | Minutes (E-domain peptide); longer as PEG-MGF | Hours — free of the IGFBP clearance that limits native IGF-1 to ~10 min |
| Based on | Insulin-like growth factor 1 | Insulin-like growth factor 1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Mechano growth factor and Long R3 IGF-1?
- Mechano growth factor is a research peptide based on Insulin-like growth factor 1; Long R3 IGF-1 is an engineered analog based on Insulin-like growth factor 1. Mechano growth factor signals at The IGF-1 core acts at IGF-1R; the distinct E-domain peptide's receptor is unidentified; Long R3 IGF-1 signals at IGF-1 receptor (IGF-1R), a receptor tyrosine kinase.
- How do the half-lives of MGF and IGF-1 LR3 compare?
- The reported circulating half-life of Mechano growth factor is Minutes (E-domain peptide); longer as PEG-MGF; Long R3 IGF-1 is Hours — free of the IGFBP clearance that limits native IGF-1 to ~10 min. These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Long R3 IGF-1 vs Mechano growth factor. Or open the interactive comparison tool to add more molecules.