Liraglutide vs Retatrutide
A once-daily GLP-1 receptor agonist; an earlier acylated analog. An investigational GIP/GLP-1/glucagon triple receptor agonist. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Liraglutide | Retatrutide | |
|---|---|---|
| Also known as | Victoza, Saxenda | — |
| Type | Analog | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GLP-1 receptor agonist (acylated, 31 aa) | GIP/GLP-1/glucagon triple agonist (acylated peptide) |
| Receptor | GLP-1 receptor (GLP-1R) | GIP + GLP-1 + glucagon receptors |
| Molecular weight | ~3,751.2 Da | ≈4,900 Da |
| Half-life | ||
| Based on | Glucagon-like peptide-1 | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Liraglutide and Retatrutide?
- Liraglutide is an engineered analog based on Glucagon-like peptide-1; Retatrutide is an engineered analog based on Glucagon-like peptide-1. Liraglutide signals at GLP-1 receptor (GLP-1R); Retatrutide signals at GIP + GLP-1 + glucagon receptors.
- How do the half-lives of Liraglutide and Retatrutide compare?
- The reported circulating half-life of Liraglutide is ~13 h; Retatrutide is ~6 days. These are reference values for the native or representative form — educational only, not dosing advice.
- Is Liraglutide the same as Victoza?
- Victoza, Saxenda are brand names of Liraglutide. This comparison describes the molecules, not branded products.
Prefer the other order? Retatrutide vs Liraglutide. Or open the interactive comparison tool to add more molecules.