Glucagon-like peptide-1 vs Brenipatide
The incretin that anchors the modern metabolic toolkit. A once-monthly dual GIP/GLP-1 agonist aimed at the brain's reward circuitry rather than the scale. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Glucagon-like peptide-1 GLP-1 | Brenipatide LY3537031 | |
|---|---|---|
| Also known as | — | — |
| Type | Endogenous | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Proglucagon-derived peptide (~30–31 aa) | GIP/GLP-1 dual agonist (acylated peptide) |
| Receptor | GLP-1 receptor (GLP-1R), a class B GPCR | GIP + GLP-1 receptors |
| Molecular weight | ~3,297.7 Da | ≈4,900 Da |
| Half-life | engineered for once-monthly dosing | |
| Based on | Native hormone | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Glucagon-like peptide-1 and Brenipatide?
- Glucagon-like peptide-1 is an endogenous hormone; Brenipatide is an engineered analog based on Glucagon-like peptide-1. Glucagon-like peptide-1 signals at GLP-1 receptor (GLP-1R), a class B GPCR; Brenipatide signals at GIP + GLP-1 receptors.
- How do the half-lives of GLP-1 and LY3537031 compare?
- The reported circulating half-life of Glucagon-like peptide-1 is ~1–2 min (native; DPP-4 cleaved); Brenipatide is engineered for once-monthly dosing. These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Brenipatide vs Glucagon-like peptide-1. Or open the interactive comparison tool to add more molecules.