Growth-hormone-releasing hormone vs CJC-1295
The hypothalamic signal that tells the pituitary to release GH. A long-acting GHRH analog engineered to stretch GH pulses. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Growth-hormone-releasing hormone GHRH | CJC-1295 | |
|---|---|---|
| Also known as | — | — |
| Type | Endogenous | Analog |
| Evidence | Established | Limited |
| Family | Growth & repair | Growth & repair |
| Class | Hypothalamic releasing peptide (44 aa) | GHRH(1-29) analog (with or without a drug-affinity complex) |
| Receptor | GHRH receptor (GHRHR), a class B GPCR | GHRH receptor (GHRHR), a class B GPCR |
| Molecular weight | ~5,039.6 Da | ≈3,647 Da |
| Half-life | ~6-8 days (DAC form); ~30 min without DAC | |
| Based on | Native hormone | Growth-hormone-releasing hormone |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Growth-hormone-releasing hormone and CJC-1295?
- Growth-hormone-releasing hormone is an endogenous hormone; CJC-1295 is an engineered analog based on Growth-hormone-releasing hormone. Growth-hormone-releasing hormone signals at GHRH receptor (GHRHR), a class B GPCR; CJC-1295 signals at GHRH receptor (GHRHR), a class B GPCR.
- How do the half-lives of GHRH and CJC-1295 compare?
- The reported circulating half-life of Growth-hormone-releasing hormone is ~7–50 min; CJC-1295 is ~6-8 days (DAC form); ~30 min without DAC. These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? CJC-1295 vs Growth-hormone-releasing hormone. Or open the interactive comparison tool to add more molecules.