Exenatide vs Survodutide
A GLP-1 receptor agonist derived from Gila monster venom (exendin-4). A dual glucagon and GLP-1 receptor agonist — the co-agonist that skips GIP and aims at the liver. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Exenatide | Survodutide BI 456906 | |
|---|---|---|
| Also known as | Byetta, Bydureon | — |
| Type | Analog | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GLP-1 receptor agonist (exendin-4, 39 aa) | Glucagon/GLP-1 dual receptor agonist (acylated peptide) |
| Receptor / target | GLP-1 receptor (GLP-1R) | Glucagon receptor (GCGR) + GLP-1 receptor |
| Molecular weight | ~4,186.6 Da | ≈4,800 Da |
| Half-life | engineered for once-weekly dosing | |
| Based on | Glucagon-like peptide-1 | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Exenatide and Survodutide?
- Exenatide is an engineered analog based on Glucagon-like peptide-1; Survodutide is an engineered analog based on Glucagon-like peptide-1. Exenatide signals at GLP-1 receptor (GLP-1R); Survodutide signals at Glucagon receptor (GCGR) + GLP-1 receptor.
- How do the half-lives of Exenatide and BI 456906 compare?
- The reported circulating half-life of Exenatide is ~2.4 h (immediate-release); Survodutide is engineered for once-weekly dosing. These are reference values for the native or representative form — educational only, not dosing advice.
- Is Exenatide the same as Byetta?
- Byetta, Bydureon are brand names of Exenatide. This comparison describes the molecules, not branded products.
Prefer the other order? Survodutide vs Exenatide. Or open the interactive comparison tool to add more molecules.