Exenatide vs Retatrutide
A GLP-1 receptor agonist derived from Gila monster venom (exendin-4). An investigational GIP/GLP-1/glucagon triple receptor agonist. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Exenatide | Retatrutide | |
|---|---|---|
| Also known as | Byetta, Bydureon | — |
| Type | Analog | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | GLP-1 receptor agonist (exendin-4, 39 aa) | GIP/GLP-1/glucagon triple agonist (acylated peptide) |
| Receptor | GLP-1 receptor (GLP-1R) | GIP + GLP-1 + glucagon receptors |
| Molecular weight | ~4,186.6 Da | ≈4,900 Da |
| Half-life | ||
| Based on | Glucagon-like peptide-1 | Glucagon-like peptide-1 |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Exenatide and Retatrutide?
- Exenatide is an engineered analog based on Glucagon-like peptide-1; Retatrutide is an engineered analog based on Glucagon-like peptide-1. Exenatide signals at GLP-1 receptor (GLP-1R); Retatrutide signals at GIP + GLP-1 + glucagon receptors.
- How do the half-lives of Exenatide and Retatrutide compare?
- The reported circulating half-life of Exenatide is ~2.4 h (immediate-release); Retatrutide is ~6 days. These are reference values for the native or representative form — educational only, not dosing advice.
- Is Exenatide the same as Byetta?
- Byetta, Bydureon are brand names of Exenatide. This comparison describes the molecules, not branded products.
Prefer the other order? Retatrutide vs Exenatide. Or open the interactive comparison tool to add more molecules.