Amylin vs Cagrilintide
Co-secreted with insulin; the satiety and gastric-emptying partner. A long-acting amylin analog built for once-weekly dosing and GLP-1 pairing. Side by side: type, evidence tier, receptor, molecular weight, and half-life — the same fields as each monograph, rearranged so the engineering difference is visible.
Amylin IAPP | Cagrilintide | |
|---|---|---|
| Also known as | — | — |
| Type | Endogenous | Analog |
| Evidence | Established | Investigational |
| Family | Incretins & metabolic | Incretins & metabolic |
| Class | Islet amyloid polypeptide (37 aa) | Long-acting amylin analog (acylated peptide) |
| Receptor | Amylin receptors (calcitonin receptor + RAMP complexes) | Amylin receptors (calcitonin receptor + RAMP) |
| Molecular weight | ~3,903.3 Da | ~4,408.9 Da |
| Half-life | ||
| Based on | Native hormone | Amylin |
Half-life bars are on a logarithmic scale across the molecules shown. Reference values for the native or representative form — educational only, not medical or dosing advice.
Common questions
- What is the difference between Amylin and Cagrilintide?
- Amylin is an endogenous hormone; Cagrilintide is an engineered analog based on Amylin. Amylin signals at Amylin receptors (calcitonin receptor + RAMP complexes); Cagrilintide signals at Amylin receptors (calcitonin receptor + RAMP).
- How do the half-lives of IAPP and Cagrilintide compare?
- The reported circulating half-life of Amylin is ~13 min (native); Cagrilintide is ~7 days (159-195 h). These are reference values for the native or representative form — educational only, not dosing advice.
Prefer the other order? Cagrilintide vs Amylin. Or open the interactive comparison tool to add more molecules.